Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids
المؤلفون المشاركون
Joshi, Asmita
Joshi, Sadhana
Chavan-Gautam, Preeti
Khot, Vinita
Kale, Anvita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming.
Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in rat placenta.
We hypothesize that these changes are mediated through micronutrient dependent regulation of enzymes in one carbon cycle.
Pregnant dams were assigned to six dietary groups with varying folic acid and vitamin B12 levels.
Vitamin B12 deficient groups were supplemented with omega-3 fatty acid.
Placental mRNA levels of enzymes, levels of phospholipids, and glutathione were determined.
Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control.
Omega-3 supplementation normalized CBS and MTHFR mRNA levels.
Increased placental phosphatidylethanolamine (PE), phosphatidylcholine (PC), in the same group was also observed.
Our data suggests that adverse effects of a maternal micronutrient imbalanced diet may be due to differential regulation of key genes encoding enzymes in one carbon cycle and omega-3 supplementation may ameliorate most of these changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khot, Vinita& Kale, Anvita& Joshi, Asmita& Chavan-Gautam, Preeti& Joshi, Sadhana. 2014. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-485115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khot, Vinita…[et al.]. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-485115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khot, Vinita& Kale, Anvita& Joshi, Asmita& Chavan-Gautam, Preeti& Joshi, Sadhana. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-485115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر