Endobronchial Perineurioma : An Unusual Soft Tissue Lesion in an Unreported Location

الملخص EN

We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue.

A 53-year-old nonsmoking female presented with a three-month history of persistent bronchitis.

A CT scan followed by bronchoscopy demonstrated an endobronchial lesion involving the left mainstem bronchus.

Removal of the lesion by bronchoscopy was accomplished.

The tumor was composed of bland spindle cells in a variably collagenized stroma.

These cells had long cytoplasmic processes.

No mitotic activity or necrosis was observed.

Neoplastic cells were immunoreactive for epithelial membrane antigen (EMA), CD34, and claudin-1.

Smooth muscle actin (SMA), desmin, and S-100 immunostains were all negative.

Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.