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Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats
المؤلفون المشاركون
Sayed, Ahmed Amir Radwan
al-Malki, Abdulrahman L.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present study aims to investigate the protective effect of bees’ honey against metanil-yellow-induced hepatotoxicity in rats.
Rats were divided into 7 groups: control group; three groups treated with 50, 100, and 200 mg/kg metanil yellow, and three groups treated with metanil yellow plus 2.5 mg·kg-1·day-1 bees’ honey for 8 weeks.
The obtained data showed that the antioxidant/anti-inflammatory activity of bees’ honey reduced the oxidative stress in the liver tissue and downregulated the inflammatory markers.
In addition, the elevated levels of AGE and the activated NF-κB in the metanil-yellow-treated animals were significantly attenuated.
Moreover, the levels of TNF-α and IL-1β were significantly attenuated as a result of bees’ honey administration.
Furthermore, the histopathological examination of the liver showed that bees’ honey reduced fatty degeneration, cytoplasmic vacuolization, and necrosis in metanil-yellow-treated rats.
In conclusion, the obtained data suggest that bees’ honey has hepatoprotective effect on acute liver injuries induced by metanil-yellow in vivo, and the results suggested that the effect of bees’ honey against metanil yellow-induced liver damage is related to its antioxidant/anti-inflammatory properties which attenuate the activation of NF-κB and its controlled genes like TNF-α and IL-1β.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. 2013. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-485250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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