Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats
Joint Authors
Sayed, Ahmed Amir Radwan
al-Malki, Abdulrahman L.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study aims to investigate the protective effect of bees’ honey against metanil-yellow-induced hepatotoxicity in rats.
Rats were divided into 7 groups: control group; three groups treated with 50, 100, and 200 mg/kg metanil yellow, and three groups treated with metanil yellow plus 2.5 mg·kg-1·day-1 bees’ honey for 8 weeks.
The obtained data showed that the antioxidant/anti-inflammatory activity of bees’ honey reduced the oxidative stress in the liver tissue and downregulated the inflammatory markers.
In addition, the elevated levels of AGE and the activated NF-κB in the metanil-yellow-treated animals were significantly attenuated.
Moreover, the levels of TNF-α and IL-1β were significantly attenuated as a result of bees’ honey administration.
Furthermore, the histopathological examination of the liver showed that bees’ honey reduced fatty degeneration, cytoplasmic vacuolization, and necrosis in metanil-yellow-treated rats.
In conclusion, the obtained data suggest that bees’ honey has hepatoprotective effect on acute liver injuries induced by metanil-yellow in vivo, and the results suggested that the effect of bees’ honey against metanil yellow-induced liver damage is related to its antioxidant/anti-inflammatory properties which attenuate the activation of NF-κB and its controlled genes like TNF-α and IL-1β.
American Psychological Association (APA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. 2013. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485250
Modern Language Association (MLA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-485250
American Medical Association (AMA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan. Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485250