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A Case of Erythrocytosis in a Patient Treated with an Aromatase Inhibitor for Breast Cancer
المؤلفون المشاركون
Iyengar, Abhinav
Sheppard, Dawn
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-07
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
A previously healthy 79-year-old female was referred to hematology for further evaluation of erythrocytosis.
Two years earlier she had been diagnosed with ER/PR-positive ductal carcinoma of the breast and was receiving hormonal therapy with exemestane.
No secondary cause of erythrocytosis was identified.
Serum erythropoietin (EPO) level was normal, and molecular testing for the JAK2 V617F and exon 12 mutations was negative.
A bone marrow biopsy showed a mild increase in erythropoiesis, and no spontaneous erythroid colonies were demonstrated.
Erythrocytosis is common reason for referral to a hematologist.
The myeloproliferative disorder, polycythemia vera, and the rare congenital polycythemias represent primary erythrocytosis.
Common secondary causes include smoking, obstructive sleep apnea, and other pulmonary diseases.
Erythrocytosis is well described with certain classes of drugs, including androgens.
We hypothesize that exemestane contributed to the development of erythrocytosis in our patient.
To our knowledge, erythrocytosis has not been previously described in association with aromatase inhibitors.
These drugs prevent the conversion of androstenedione and testosterone to estrogen; thus the physiologic mechanisms may be similar to those responsible for erythrocytosis seen with exogenous androgens.
These mechanisms are not well understood, but may include altered iron metabolism by a reduction in hepcidin levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iyengar, Abhinav& Sheppard, Dawn. 2013. A Case of Erythrocytosis in a Patient Treated with an Aromatase Inhibitor for Breast Cancer. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-485309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iyengar, Abhinav& Sheppard, Dawn. A Case of Erythrocytosis in a Patient Treated with an Aromatase Inhibitor for Breast Cancer. Case Reports in Hematology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-485309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iyengar, Abhinav& Sheppard, Dawn. A Case of Erythrocytosis in a Patient Treated with an Aromatase Inhibitor for Breast Cancer. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-485309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485309
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