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Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain : Neurochemical State Dependence of Global and Local Topological Properties
المؤلفون المشاركون
Gozzi, Alessandro
Bifone, Angelo
Chessa, Alessandro
Schwarz, Adam J.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Network analysis of functional imaging data reveals emergent features of the brain as a function of its topological properties.
However, the brain is not a homogeneous network, and the dependence of functional connectivity parameters on neuroanatomical substrate and parcellation scale is a key issue.
Moreover, the extent to which these topological properties depend on underlying neurochemical changes remains unclear.
In the present study, we investigated both global statistical properties and the local, voxel-scale distribution of connectivity parameters of the rat brain.
Different neurotransmitter systems were stimulated by pharmacological challenge (d-amphetamine, fluoxetine, and nicotine) to discriminate between stimulus-specific functional connectivity and more general features of the rat brain architecture.
Although global connectivity parameters were similar, mapping of local connectivity parameters at high spatial resolution revealed strong neuroanatomical dependence of functional connectivity in the rat brain, with clear differentiation between the neocortex and older brain regions.
Localized foci of high functional connectivity independent of drug challenge were found in the sensorimotor cortices, consistent with the high neuronal connectivity in these regions.
Conversely, the topological properties and node roles in subcortical regions varied with neurochemical state and were dependent on the specific dynamics of the different functional processes elicited.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schwarz, Adam J.& Gozzi, Alessandro& Chessa, Alessandro& Bifone, Angelo. 2012. Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain : Neurochemical State Dependence of Global and Local Topological Properties. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-485341
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schwarz, Adam J.…[et al.]. Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain : Neurochemical State Dependence of Global and Local Topological Properties. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-485341
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schwarz, Adam J.& Gozzi, Alessandro& Chessa, Alessandro& Bifone, Angelo. Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain : Neurochemical State Dependence of Global and Local Topological Properties. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-485341
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485341
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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