Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies : A Critical Issue for the Field of Gene Therapy
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Integrating gene delivery systems allow for a more stable transgene expression in mammalian cells than the episomal ones.
However, the integration of the shuttle vector within the cellular chromosomal DNA is associated with the risk of insertional mutagenesis, which, in turn, may cause malignant cell transformation.
The use of a retroviral-derived vector system was responsible for the development of leukemia in five children, who participated in various clinical trials for the treatment of severe combined immunodeficiency (SCID-X1) in France and in the United Kingdom.
Unfortunately, the hematological malignancy claimed the life of one patient in 2004, who was enrolled in the French clinical trial.
In addition, adeno-associated-viral-(AAV-) mediated gene transfer induced tumors in animal models, whereas the Sleeping Beauty (SB) DNA transposon system was associated with insertional mutagenesis events in cell culture systems.
On these grounds, it is necessary to develop safer gene delivery systems for the genetic manipulation of mammalian cells.
This paper discusses the latest achievements that have been reported in the field of vector design.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Romano, Gaetano. 2012. Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies : A Critical Issue for the Field of Gene Therapy. ISRN Oncology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-485396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Romano, Gaetano. Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies : A Critical Issue for the Field of Gene Therapy. ISRN Oncology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-485396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Romano, Gaetano. Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies : A Critical Issue for the Field of Gene Therapy. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-485396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر