Association of Ultrasonographic Parameters with Subclinical White-Matter Hyperintensities in Hypertensive Patients
المؤلفون المشاركون
Tsivgoulis, Georgios
Vadikolias, Konstantinos
Piperidou, Charitomeni
Artemis, Dimitrios
Tripsianis, Grigorios
Heliopoulos, Ioannis
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Purpose.
Cerebral white matter hyperintensities (WMHs) are regarded as typical MRI expressions of small-vessel disease (SVD) and are common in hypertensive patients.
Hypertension induces pathologic changes in macrocirculation and in microcirculation.
Changes in microcirculation may lead to SVD of brain and consequently to hypertensive end-organ damage.
This damage is regarded the result of interactions between the macrovascular and microvascular levels.
We sought to investigate the association of cerebral WMHs with ultrasonographic parameters of cerebral macrocirculation evaluated by carotid duplex ultrasound (CDU) and transcranial doppler (TCD).
Subjects and Methods.
The study was prospective, cross-sectional and consecutive and included hypertensive patients with brain MRI with WMHs.
Patients underwent CDU and TCD.
The clinical variables recorded were demographic characteristics (age, gender, race) and vascular risk factors (hypertension, diabetic mellitus, hypercholesterolemia, current smoking, and body mass index).
Excluded from the study were patients with history of clinical stroke (including lacunar stroke and hemorrhagic) or transient ischemic attack (either hemispheric or ocular), hemodynamically significant (>50%) extra- or intracranial stenosis, potential sources of cardioembolism, and absent transtemporal windows.
WMHs were quantified with the use of a semiquantitative visual rating method.
Ultrasound parameters investigated were (1) common carotid artery (CCA) diameter and intima-media thickness, (2) blood flow velocity in the CCA and internal carotid artery (ICA), and (3) blood flow velocity and pulsatility index of middle cerebral artery (MCA).
Results.
A total of 52 patients fulfilled the study inclusion criteria (mean age 71.4±4.5 years, 54% men, median WMH-score: 20).
The only two ultrasound parameters that were independently associated with WMH score in multivariate linear regression models adjusting for demographic characteristics and vascular risk factors were increased mean common carotid artery (CCA) diameter (beta=0.784, SE=0.272, P=0.006, R2=23.9%) and increased middle cerebral artery pulsatility index (MCA-PI; beta=0.262, SE=0.110, P=0.025, R2=9.0%).
Among all ultrasound parameters the highest AUC (areas under the receiver operating characteristic curve) were documented for MCA-PI (AUC=0.82, 95% CI = 0.68−0.95, P<0.001) and mean CCA diameter (AUC=0.80, 95% CI = 0.67−0.92, P<0.001).
Conclusions.
Our study showed that in hypertensive individuals with brain SVD the extent of structural changes in cerebral microcirculation as reflected by WMHs burden is associated with the following ultrasound parameters of cerebral macrocirculation: CCA diameter and MCA-PI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heliopoulos, Ioannis& Artemis, Dimitrios& Vadikolias, Konstantinos& Tripsianis, Grigorios& Piperidou, Charitomeni& Tsivgoulis, Georgios. 2012. Association of Ultrasonographic Parameters with Subclinical White-Matter Hyperintensities in Hypertensive Patients. Cardiovascular Psychiatry and Neurology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heliopoulos, Ioannis…[et al.]. Association of Ultrasonographic Parameters with Subclinical White-Matter Hyperintensities in Hypertensive Patients. Cardiovascular Psychiatry and Neurology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-485417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heliopoulos, Ioannis& Artemis, Dimitrios& Vadikolias, Konstantinos& Tripsianis, Grigorios& Piperidou, Charitomeni& Tsivgoulis, Georgios. Association of Ultrasonographic Parameters with Subclinical White-Matter Hyperintensities in Hypertensive Patients. Cardiovascular Psychiatry and Neurology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر