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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue
المؤلفون المشاركون
Hosur, Kavita B.
Pyaram, Kalyani
Jotwani, Ravi
Liang, Shuang
Chavakis, Triantafyllos
Hajishengallis, George
Shin, Jieun
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Developmental endothelial locus-1 (Del-1) is an endothelial cell-secreted protein that limits the recruitment of neutrophils by antagonizing the interaction between the LFA-1 integrin on neutrophils and the intercellular adhesion molecule (ICAM)-1 on endothelial cells.
Mice with genetic or age-associated Del-1 deficiency exhibit increased neutrophil infiltration in the periodontium resulting in inflammatory bone loss.
Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation.
Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin).
Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment.
Strikingly, Del-1 inhibited ICAM-1-dependent chemokine release (CXCL2, CCL3) by neutrophils.
Therefore, Del-1 could potentially suppress the amplification of inflammatory cell recruitment mediated through chemokine release by infiltrating neutrophils.
Interestingly, Del-1 was itself regulated by inflammatory stimuli, which generally exerted opposite effects on adhesion molecule expression.
The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shin, Jieun& Hosur, Kavita B.& Pyaram, Kalyani& Jotwani, Ravi& Liang, Shuang& Chavakis, Triantafyllos…[et al.]. 2013. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shin, Jieun…[et al.]. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Clinical and Developmental Immunology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-485526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shin, Jieun& Hosur, Kavita B.& Pyaram, Kalyani& Jotwani, Ravi& Liang, Shuang& Chavakis, Triantafyllos…[et al.]. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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