Hsp70 and Its Molecular Role in Nervous System Diseases
المؤلفون المشاركون
Sconzo, Gabriella
Turturici, Giuseppina
Geraci, Fabiana
المصدر
Biochemistry Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-24
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma.
The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a deleterious role in some diseases.
Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis).
The worldwide incidence of neurodegenerative diseases is high.
As neurodegenerative diseases disproportionately affect older individuals, disease-related morbidity has increased along with the general increase in longevity.
An understanding of the underlying mechanisms that lead to neurodegeneration is key to identifying methods of prevention and treatment.
Investigators have observed protective effects of HSPs induced by preconditioning, overexpression, or drugs in a variety of models of brain disease.
Experimental data suggest that manipulation of the cellular stress response may offer strategies to protect the brain during progression of neurodegenerative disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Turturici, Giuseppina& Sconzo, Gabriella& Geraci, Fabiana. 2011. Hsp70 and Its Molecular Role in Nervous System Diseases. Biochemistry Research International،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-485560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Turturici, Giuseppina…[et al.]. Hsp70 and Its Molecular Role in Nervous System Diseases. Biochemistry Research International No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-485560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Turturici, Giuseppina& Sconzo, Gabriella& Geraci, Fabiana. Hsp70 and Its Molecular Role in Nervous System Diseases. Biochemistry Research International. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-485560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر