Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension : A Computational Study with Validation Using Animal Models
المؤلفون المشاركون
Tan, Wei
Hunter, Kendall S.
Shandas, Robin
Su, Zhenbi
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We develop a simple computational model based on measurements from a hypoxic neonatal calf model of pulmonary hypertension (PH) to investigate the interplay between vascular and ventricular measures in the setting of progressive PH.
Model parameters were obtained directly from in vivo and ex vivo measurements of neonatal calves.
Seventeen sets of model-predicted impedance and mean pulmonary arterial pressure (mPAP) show good agreement with the animal measurements, thereby validating the model.
Next, we considered a predictive model in which three parameters, PVR, elastic modulus (EM), and arterial thickness, were varied singly from one simulation to the next to study their individual roles in PH progression.
Finally, we used the model to predict the individual impacts of clinical (vasodilatory) and theoretical (compliance increasing) PH treatments on improving pulmonary hemodynamics.
Our model (1) displayed excellent patient-specific agreement with measured global pulmonary parameters; (2) quantified relationships between PVR and mean pressure and PVS and pulse pressure, as well as studiying the right ventricular (RV) afterload, which could be measured as a hydraulic load calculated from spectral analysis of pulmonary artery pressure and flow waves; (3) qualitatively confirmed the derangement of vascular wall shear stress in progressive PH; and (4) established that decreasing proximal vascular stiffness through a theoretical treatment of reversing proximal vascular remodeling could decrease RV afterload.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Zhenbi& Tan, Wei& Shandas, Robin& Hunter, Kendall S.. 2013. Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension : A Computational Study with Validation Using Animal Models. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485575
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Zhenbi…[et al.]. Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension : A Computational Study with Validation Using Animal Models. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-485575
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Zhenbi& Tan, Wei& Shandas, Robin& Hunter, Kendall S.. Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension : A Computational Study with Validation Using Animal Models. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485575
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485575
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر