Identification of Robust Pathway Markers for Cancer through Rank-Based Pathway Activity Inference
المؤلفون المشاركون
Khunlertgit, Navadon
Yoon, Byung-Jun
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
One important problem in translational genomics is the identification of reliable and reproducible markers that can be used to discriminate between different classes of a complex disease, such as cancer.
The typical small sample setting makes the prediction of such markers very challenging, and various approaches have been proposed to address this problem.
For example, it has been shown that pathway markers, which aggregate the gene activities in the same pathway, tend to be more robust than gene markers.
Furthermore, the use of gene expression ranking has been demonstrated to be robust to batch effects and that it can lead to more interpretable results.
In this paper, we propose an enhanced pathway activity inference method that uses gene ranking to predict the pathway activity in a probabilistic manner.
The main focus of this work is on identifying robust pathway markers that can ultimately lead to robust classifiers with reproducible performance across datasets.
Simulation results based on multiple breast cancer datasets show that the proposed inference method identifies better pathway markers that can predict breast cancer metastasis with higher accuracy.
Moreover, the identified pathway markers can lead to better classifiers with more consistent classification performance across independent datasets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khunlertgit, Navadon& Yoon, Byung-Jun. 2013. Identification of Robust Pathway Markers for Cancer through Rank-Based Pathway Activity Inference. Advances in Bioinformatics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-485586
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khunlertgit, Navadon& Yoon, Byung-Jun. Identification of Robust Pathway Markers for Cancer through Rank-Based Pathway Activity Inference. Advances in Bioinformatics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-485586
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khunlertgit, Navadon& Yoon, Byung-Jun. Identification of Robust Pathway Markers for Cancer through Rank-Based Pathway Activity Inference. Advances in Bioinformatics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-485586
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485586
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر