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Pyrrolidine Dithiocarbamate Attenuates Paraquat-Induced Lung Injury in Rats
المؤلفون المشاركون
Wu, Qing
Zhou, Zhijun
Wu, Qiangen
Shao, Chunfeng
Huang, Min
Chang, Xiuli
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Paraquat (PQ) has been demonstrated that the main target organ for the toxicity is the lung.
This study aimed to investigate the potential protective effect of PDTC on the PQ-induced pulmonary damage.
Fifty-four rats were divided into control, PQ-treated and PQ+PDTC-treated groups.
Rats in the PQ group were administrated 40 mg/kg PQ by gastric gavage, and PDTC group with 40 mg/kg PQ followed by injection of 120 mg/kg PDTC (IP).
On the days 3, 7, 14 and 21 after treatments, the activities of GSH-Px, SOD, MDA level and the content of HYP were measured.
TGF-β1 mRNA and protein were assayed by RT-PCR and ELISA.
MDA level in plasma and BALF was increased and the activities of GSH-Px and SOD were decreased significantly in the PQ-treated groups (P<.05) compared with control group.
While the activities of GSH-Px and SOD in the PQ+PDTC-treated groups was markedly higher than that of PQ-treated groups (P<.05), and in contrast, MDA level was lower.
TGF-β1 mRNA and protein were significantly lower in the PQ+PDTC-treated groups than that of PQ-treated groups (P<.05).
The histopathological changes in the PQ+PDTC-treated groups were milder than those of PQ groups.
Our results suggested that PDTC treatment significantly attenuated paraquat-induced pulmonary damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Xiuli& Shao, Chunfeng& Wu, Qing& Wu, Qiangen& Huang, Min& Zhou, Zhijun. 2009. Pyrrolidine Dithiocarbamate Attenuates Paraquat-Induced Lung Injury in Rats. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Xiuli…[et al.]. Pyrrolidine Dithiocarbamate Attenuates Paraquat-Induced Lung Injury in Rats. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-485685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Xiuli& Shao, Chunfeng& Wu, Qing& Wu, Qiangen& Huang, Min& Zhou, Zhijun. Pyrrolidine Dithiocarbamate Attenuates Paraquat-Induced Lung Injury in Rats. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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