Effects of bFGF on the Modulation of Apoptosis in Gingival Fibroblasts with Different Host Ages

المؤلفون المشاركون

Tanimoto, Kotaro
Mitsuyoshi, Tomomi
Tanne, Yuki
Hirose, Naoto
Kunimatsu, Ryo
Tanne, Kazuo
Ohkuma, Satoru
Su, Shaoching
Yoshimi, Yuki

المصدر

International Journal of Dentistry

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-09-10

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

طب الأسنان

الملخص EN

The purpose of this study was to investigate the effects of basic fibroblast growth factor (bFGF) treatment on the proliferation and apoptosis of cultured gingival fibroblasts (GFs).

Human GFs were isolated from the palatal gingival tissues of 16 healthy volunteers ranging in the age from 9 to 35 years old.

Cultured GFs were subjected to the analyses for cell proliferation by ELISA assay, gene expression by RT-PCR analysis, and apoptosis potency by caspase-3 assay.

The cell proliferation activity and gene expression of type-I collagen and caspase-3 activity were enhanced significantly by the treatment with bFGF in cultured GFs.

Furthermore, the activity of caspase-3 in cultured GFs from young subjects was significantly higher than that in GFs from adults.

It is shown that bFGF significantly enhances the gene expression of type-I collagen in cultured fibroblasts from human gingival tissues.

It also demonstrated that bFGF modulates the apoptosis of periodontal fibroblasts, and the effect is higher in young subjects, indicating a significant role of bFGF in the prevention of scar formation during wound healing.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tanimoto, Kotaro& Ohkuma, Satoru& Tanne, Yuki& Kunimatsu, Ryo& Hirose, Naoto& Mitsuyoshi, Tomomi…[et al.]. 2013. Effects of bFGF on the Modulation of Apoptosis in Gingival Fibroblasts with Different Host Ages. International Journal of Dentistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485694

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tanimoto, Kotaro…[et al.]. Effects of bFGF on the Modulation of Apoptosis in Gingival Fibroblasts with Different Host Ages. International Journal of Dentistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-485694

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tanimoto, Kotaro& Ohkuma, Satoru& Tanne, Yuki& Kunimatsu, Ryo& Hirose, Naoto& Mitsuyoshi, Tomomi…[et al.]. Effects of bFGF on the Modulation of Apoptosis in Gingival Fibroblasts with Different Host Ages. International Journal of Dentistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485694

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-485694