Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis
المؤلفون المشاركون
Yang, Chung-Zhing
Chang, Ching-Ping
Cheong, Chong-Un
Chao, Chien-Ming
Chio, Chung-Ching
Cheng, Bor-Chih
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
It remains unclear whether etanercept penetrates directly into the contused brain and improves the outcomes of TBI by attenuating brain contents of TNF-α and/or stimulating newly formed neurogenesis.
Rats that sustained TBI are immediately treated with etanercept.
Acute neurological and motor injury is assessed in all rats the day prior to and 7 days after surgery.
The numbers of the colocalizations of 5-bromodeoxyuridine and doublecortin specific markers in the contused brain injury that occurred during TBI were counted by immunofluorescence staining.
Enzyme immunoassay for quantitative determination of TNF-α or etanercept in brain tissues is also performed.
Seven days after systemic administration of etanercept, levels of etanercept can be detected in the contused brain tissues.
In addition, neurological and motor deficits, cerebral contusion, and increased brain TNF-α contents caused by TBI can be attenuated by etanercept therapy.
Furthermore, the increased numbers of the colocalizations of 5-bromodeoxyuridine and doublecortin specific markers in the contused brain tissues caused by TBI can be potentiated by etanercept therapy.
These findings indicate that systemically administered etanercept may penetrate directly into the contused brain tissues and may improve outcomes of TBI by reducing brain contents of TNF-α and by stimulating newly formed neurogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheong, Chong-Un& Chang, Ching-Ping& Chao, Chien-Ming& Cheng, Bor-Chih& Yang, Chung-Zhing& Chio, Chung-Ching. 2013. Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheong, Chong-Un…[et al.]. Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-485798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheong, Chong-Un& Chang, Ching-Ping& Chao, Chien-Ming& Cheng, Bor-Chih& Yang, Chung-Zhing& Chio, Chung-Ching. Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر