![](/images/graphics-bg.png)
Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
المؤلفون المشاركون
Kaplan, İbrahim
Güzel, Abdulmenap
Selimoğlu Şen, Hadice
Ece, Aydın
Şen, Velat
Deveci, Engin
Doğan, Erdal
Söker, Sevda
Uluca, Ünal
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model.
Twenty-eight male Wistar albino rats weighing 300–350 g were allocated randomly to four groups.
In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously.
In group 2, rats received standard ventilation (SV) in addition to NS.
In group 3, hydrochloric acid was injected into the lungs and rats received SV.
In group 4, rats received SV and 100 µg/kg intraperitoneal dexmedetomidine before intratracheal HCl instillation.
Blood samples and liver tissue specimens were examined by biochemical, histopathological, and immunohistochemical methods.
Acute lung injury (ALI) was found to be associated with increased malondialdehyde (MDA), total oxidant activity (TOA), oxidative stress index (OSI), and decreased total antioxidant capacity (TAC).
Significantly decreased MDA, TOA, and OSI levels and significantly increased TAC levels were found with dexmedetomidine injection in group 4 (P<0.05).
The highest histologic injury scores were detected in group 3.
Enhanced hepatic vascular endothelial growth factor (VEGF) expression and reduced CD68 expression were found in dexmedetomidine group compared with the group 3.
In conclusion, the presented data provide the first evidence that dexmedetomidine has a protective effect on experimental liver injury induced by ALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Şen, Velat& Güzel, Abdulmenap& Selimoğlu Şen, Hadice& Ece, Aydın& Uluca, Ünal& Söker, Sevda…[et al.]. 2014. Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Şen, Velat…[et al.]. Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-485895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Şen, Velat& Güzel, Abdulmenap& Selimoğlu Şen, Hadice& Ece, Aydın& Uluca, Ünal& Söker, Sevda…[et al.]. Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)