Three-Dimensional In Vitro Models of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria
المؤلفون المشاركون
Fitzgerald, Liam E.
Abendaño, Naiara
Juste, Ramón A.
Alonso-Hearn, Marta
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium bovis, and Mycobacterium avium subsp.
paratuberculosis can survive within host macrophages in a dormant state, encased within an organized aggregate of immune host cells called granuloma.
Granulomas consist of uninfected macrophages, foamy macrophages, epithelioid cells, and T lymphocytes accumulated around infected macrophages.
Within granulomas, activated macrophages can fuse to form multinucleated giant cells, also called giant Langhans cells.
A rim of T lymphocytes surrounds the core, and a tight coat of fibroblast closes the structure.
Several in vivo models have been used to study granuloma’s structure and function, but recently developed in vitro models of granuloma show potential for closer observation of the early stages of host’s responses to live mycobacteria.
This paper reviews culture conditions that resulted in three-dimensional granulomas, formed by the adhesion of cell populations in peripheral blood mononuclear cells infected with mycobacteria.
The similarities of these models to granulomas encountered in clinical specimens include cellular composition, granulomas’ cytokine production, and cell surface antigens.
A reliable in vitro dormancy model may serve as a useful platform to test whether drug candidates can kill dormant mycobacteria.
Novel drugs that target dormancy-specific pathways may shorten the current long, difficult treatments necessary to cure mycobacterial diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fitzgerald, Liam E.& Abendaño, Naiara& Juste, Ramón A.& Alonso-Hearn, Marta. 2014. Three-Dimensional In Vitro Models of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fitzgerald, Liam E.…[et al.]. Three-Dimensional In Vitro Models of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-485986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fitzgerald, Liam E.& Abendaño, Naiara& Juste, Ramón A.& Alonso-Hearn, Marta. Three-Dimensional In Vitro Models of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-485986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر