Differential Expression of Cholecystokinin A Receptor in Gallbladder Cancer in the Young and Elderly Suggests Two Subsets of the Same Disease?
المؤلفون المشاركون
Goel, Sudhir K.
Nigam, Jaya
Mahdi, Abbas Ali
Kumar, Sandeep
Chandra, Abhijit
Kazmi, Hasan Raza
Singh, Anshuman
Parmar, Devendra
Baghel, Kavita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Cholecystokinin type A receptor (CCKAR) is known to be overexpressed in variety of human malignancies but information regarding its expression in gallbladder cancer (GBC) is limited.
Attempts were now made to investigate expression pattern of CCKAR mRNA and protein in controls and GBC patients and correlate it with various clinicopathological parameters following surgical resection.
Materials and Methods.
Gallbladder tissue samples from 64 subjects (GBC: 39; control: 25) were studied.
Expression of CCKAR mRNA was evaluated by reverse transcriptase-polymerase chain reaction and confirmed using real-time polymerase chain reaction.
Protein expression was studied by enzyme-linked immunosorbent assay.
Results.
Significantly higher expression of CCKAR mRNA (P<0.0001) and protein (P<0.0001) was observed in GBC tissues.
Overexpression was also observed for stage III and in moderately and poorly differentiated tumors.
When the clinicopathological parameters were compared, we found age dependent decrease in CCKAR expression.
Relatively higher expression of CCKAR was observed in younger patients (age < 45 years) having more aggressive disease when compared with elderly ones (age ≥ 45 years).
Conclusions.
Age related differential expression of CCKAR in GBC may suggest two possible variants of the disease in this endemic belt.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kazmi, Hasan Raza& Chandra, Abhijit& Baghel, Kavita& Singh, Anshuman& Nigam, Jaya& Parmar, Devendra…[et al.]. 2014. Differential Expression of Cholecystokinin A Receptor in Gallbladder Cancer in the Young and Elderly Suggests Two Subsets of the Same Disease?. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-486150
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kazmi, Hasan Raza…[et al.]. Differential Expression of Cholecystokinin A Receptor in Gallbladder Cancer in the Young and Elderly Suggests Two Subsets of the Same Disease?. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-486150
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kazmi, Hasan Raza& Chandra, Abhijit& Baghel, Kavita& Singh, Anshuman& Nigam, Jaya& Parmar, Devendra…[et al.]. Differential Expression of Cholecystokinin A Receptor in Gallbladder Cancer in the Young and Elderly Suggests Two Subsets of the Same Disease?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-486150
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486150
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر