Actinobacillus succinogenes ATCC 55618 Fermentation Medium Optimization for the Production of Succinic Acid by Response Surface Methodology
المؤلفون المشاركون
Wang, Cheng-Cheng
Wan, Duan-Ji
Li, Hong-Mei
Zhu, Li-Wen
Tang, Ya-Jie
Liu, Rui-Sang
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
As a potential intermediary feedstock, succinic acid takes an important place in bulk chemical productions.
For the first time, a method combining Plackett-Burman design (PBD), steepest ascent method (SA), and Box-Behnken design (BBD) was developed to optimize Actinobacillus succinogenes ATCC 55618 fermentation medium.
First, glucose, yeast extract, and MgCO3 were identified to be key medium components by PBD.
Second, preliminary optimization was run by SA method to access the optimal region of the key medium components.
Finally, the responses, that is, the production of succinic acid, were optimized simultaneously by using BBD, and the optimal concentration was located to be 84.6 g L−1 of glucose, 14.5 g L−1 of yeast extract, and 64.7 g L−1 of MgCO3.
Verification experiment indicated that the maximal succinic acid production of 52.7±0.8 g L−1 was obtained under the identified optimal conditions.
The result agreed with the predicted value well.
Compared with that of the basic medium, the production of succinic acid and yield of succinic acid against glucose were enhanced by 67.3% and 111.1%, respectively.
The results obtained in this study may be useful for the industrial commercial production of succinic acid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Li-Wen& Wang, Cheng-Cheng& Liu, Rui-Sang& Li, Hong-Mei& Wan, Duan-Ji& Tang, Ya-Jie. 2012. Actinobacillus succinogenes ATCC 55618 Fermentation Medium Optimization for the Production of Succinic Acid by Response Surface Methodology. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Li-Wen…[et al.]. Actinobacillus succinogenes ATCC 55618 Fermentation Medium Optimization for the Production of Succinic Acid by Response Surface Methodology. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-486195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Li-Wen& Wang, Cheng-Cheng& Liu, Rui-Sang& Li, Hong-Mei& Wan, Duan-Ji& Tang, Ya-Jie. Actinobacillus succinogenes ATCC 55618 Fermentation Medium Optimization for the Production of Succinic Acid by Response Surface Methodology. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر