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Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota : A Three-Way Crosstalk
المؤلفون المشاركون
McCormick, Beth A.
Srikanth, C. V.
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-10-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The mucosal surfaces of the gastrointestinal tract harbor a vast number of commensal microbiota that have coevolved with the host, and in addition display one of the most complex relationships with the host.
This relationship affects several important aspects of the biology of the host including the synthesis of nutrients, protection against infection, and the development of the immune system.
On the other hand, despite the existence of several lines of mucosal defense mechanisms, pathogenic organisms such as Shigella and Salmonella have evolved sophisticated virulence strategies for breaching these barriers.
The constant challenge from these pathogens and the attempts by the host to counter them set up a dynamic equilibrium of cellular and molecular crosstalk.
Even slight perturbations in this equilibrium may be detrimental to the host leading to severe bacterial infection or even autoimmune diseases like inflammatory bowel disease.
Several experimental model systems, including germ-free mice and antibiotic-treated mice, have been used by various researchers to study this complex relationship.
Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Srikanth, C. V.& McCormick, Beth A.. 2008. Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota : A Three-Way Crosstalk. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-486236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Srikanth, C. V.& McCormick, Beth A.. Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota : A Three-Way Crosstalk. Interdisciplinary Perspectives on Infectious Diseases No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-486236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Srikanth, C. V.& McCormick, Beth A.. Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota : A Three-Way Crosstalk. Interdisciplinary Perspectives on Infectious Diseases. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-486236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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