The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease : An Eleven-Year Follow-Up Study
المؤلفون المشاركون
Goodarzi, Mark O.
Lee, I-Te
Rotter, Jerome I.
Liang, Kae-Woei
Lee, Wen-Lieng
Lee, Wen-Jane
Chen, Yii-der Ida
Sheu, Wayne Huey-Herng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
We examined whether the variant at chromosome 9p21, rs4977574, was associated with long-term cardiovascular mortality in Han Chinese patients with coronary artery disease (CAD).
Methodology.
Subjects who underwent coronary angiography for chest pain were consecutively enrolled.
Fasting blood samples were collected for laboratory and genotype assessments.
The information was correlated with data collected from the national death database.
Results.
There were 925 cases with CAD and 634 without CAD enrolled in the present study.
The G allele conferred a significant increase in risk of CAD (odds ratio = 1.47, P=0.003 in the dominant model; odds ratio = 1.36, P=0.018 in the recessive model).
During a median of 11 years (inter-quartile range between 5.2 and 12.5 years) of follow-up, neither the total nor the cardiovascular mortality was different among CAD subjects with different genotypes.
Using Cox regression analysis, genotypes of rs4977574 still failed to predict cardiovascular mortality (hazard ratio = 1.25, P=0.138 in the dominant model; hazard ratio = 1.05, P=0.729 in the recessive model).
Conclusions.
The rs4977574 at chromosome 9p21 is associated with presence of CAD in Han Chinese.
However, rs4977574 could not predict cardiovascular mortality in these CAD subjects during the eleven-year period of the study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, I-Te& Goodarzi, Mark O.& Lee, Wen-Jane& Rotter, Jerome I.& Chen, Yii-der Ida& Liang, Kae-Woei…[et al.]. 2014. The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease : An Eleven-Year Follow-Up Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-486240
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, I-Te…[et al.]. The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease : An Eleven-Year Follow-Up Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-486240
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, I-Te& Goodarzi, Mark O.& Lee, Wen-Jane& Rotter, Jerome I.& Chen, Yii-der Ida& Liang, Kae-Woei…[et al.]. The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease : An Eleven-Year Follow-Up Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-486240
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486240
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر