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High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats
المؤلفون المشاركون
Cerf, Marlon E.
Chapman, Charna S.
Louw, Johan
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
High-fat programming, by exposure to a high-saturated-fat diet in utero and/or during lactation, compromises beta-cell development and function in neonatal and weanling offspring.
Therefore, high-fat programming effects were investigated on metabolism and islet architecture in young adult rats.
Three-month-old male and female Wistar rat offspring were studied: HFG (maintained on a high-fat diet throughout fetal life), HFP (high-fat diet maintenance from birth to 3 months), and HFGP (high-fat diet maintenance throughout fetal and postnatal life).
Control rats were maintained on a standard laboratory diet.
Pancreata were double immunolabeled for insulin and glucagon to assess islet morphology and with Ki-67 to determine islet and acinar cell proliferation.
HFP and HFGP males were heavier, hyperleptinemic, and hyperinsulinemic.
Hyperglycemia presented in HFP males, HFP females, and HFGP males.
HFGP males and HFP females were insulin resistant.
HFP males displayed beta- and alpha-cell hyperplasia with alpha-cell hypertrophy evident in HFP females.
Acinar cell proliferation rates were increased in HFP males.
Postnatal high-fat programming induced the most diabetogenic phenotype with high-fat maintenance throughout fetal and postnatal life resulting in a severely obese phenotype.
Fetal and postnatal nutrition shapes offspring health outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cerf, Marlon E.& Chapman, Charna S.& Louw, Johan. 2012. High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486268
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cerf, Marlon E.…[et al.]. High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats. ISRN Endocrinology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-486268
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cerf, Marlon E.& Chapman, Charna S.& Louw, Johan. High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486268
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486268
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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