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Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7)
المؤلفون المشاركون
Banerji, Aniruddha
Dutta, Anindita
Das, Shamik
Sen, Triparna
Chatterjee, Amitava
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Vitamin A derivative all-trans retinoic acid (ATRA) is considered as a potent chemotherapeutic drug for its capability of regulating cell growth and differentiation.
We studied the effect of ATRA on MMP-2 in MCF-7, human breast cancer cells, and the probable signaling pathways which are affected by ATRA on regulating pro-MMP-2 activity and expression.
Methods.
Gelatin zymography, RT-PCR, ELISA, Western blot, Immunoprecipitation, and Cell adhesion assay are used.
Results.
Gelatin zymography showed that ATRA caused a dose-dependent inhibition of pro-MMP-2 activity.
ATRA treatment downregulates the expression of MT1-MMP, EMMPRIN, FAK, NF-kB, and p-ERK.
However, expression of E-cadherin, RAR, and CRABP increased upon ATRA treatment.
Binding of cells to extra cellular matrix (ECM) protein fibronectin reduced significantly after ATRA treatment.
Conclusions.
The experimental findings clearly showed the inhibition of MMP-2 activity upon ATRA treatment.
This inhibitory effect of ATRA on MMP-2 activity in human breast cancer cells (MCF-7) may result due to its inhibitory effect on MT1-MMP, EMMPRIN, and upregulation of TIMP-2.
This study is focused on the effect of ATRA on MMP, MMP-integrin-E-cadherin interrelationship, and also the effect of the drug on different signaling molecules which may involve in the progression of malignant tumor development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dutta, Anindita& Sen, Triparna& Banerji, Aniruddha& Das, Shamik& Chatterjee, Amitava. 2009. Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7). Journal of Oncology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-486316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dutta, Anindita…[et al.]. Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7). Journal of Oncology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-486316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dutta, Anindita& Sen, Triparna& Banerji, Aniruddha& Das, Shamik& Chatterjee, Amitava. Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7). Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-486316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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