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Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway
المؤلفون المشاركون
Abraham, Nader G.
Cao, Jian
Puri, Nitin
Kappas, Attallah
Sodhi, Komal
Bellner, Lars
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Insulin resistance, with adipose tissue dysfunction, is one of the hallmarks of metabolic syndrome.
We have reported a metabolic syndrome-like phenotype in heme oxygenase (HO)-2 knockout mice, which presented with concurrent HO-1 deficiency and were amenable to rescue by an EET analog.
Apo A-I mimetic peptides, such as L-4F, have been shown to induce HO-1 expression and decrease oxidative stress and adiposity.
In this study we aimed to characterize alleviatory effects of HO-1 induction (if any) on metabolic imbalance observed in HO-2 KO mice.
In this regard, HO-2(−/−) mice were injected with 2 mg/kg/day L-4F, or vehicle, i.p., for 6 weeks.
As before, compared to WT animals, the HO-2 null mice were obese, displayed insulin resistance, and had elevated blood pressure.
These changes were accompanied by enhanced tissue (hepatic) oxidative stress along with attenuation of HO-1 expression and activity and reduced adiponectin, pAMPK, and LKB1 expression.
Treatment with L-4F restored HO-1 expression and activity and increased adiponectin, LKB1, and pAMPK in the HO-2(−/−) mice.
These alterations resulted in a decrease in blood pressure, insulin resistance, blood glucose, and adiposity.
Taken together, our results show that a deficient HO-1 response, in a state with reduced HO-2 basal levels, is accompanied by disruption of metabolic homeostasis which is successfully restored by an HO-1 inducer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Jian& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Abraham, Nader G.& Kappas, Attallah. 2012. Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486350
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Jian…[et al.]. Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-486350
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Jian& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Abraham, Nader G.& Kappas, Attallah. Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486350
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486350
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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