Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes : A Preliminary Report
المؤلفون المشاركون
Ashshi, Ahmed Mohamed
Refaat, Bassem
El-Shemi, Adel Galal
AlZanbagi, Adnan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
To measure the effect of pegylated interferon-α therapy on serum activin-A, activin-B, and follistatin and their correlation with viral load and liver fibrosis in chronic hepatitis C (CHC).
Methods.
This study was cross-sectional and sera were collected from 165 participants classified into 7 groups: 40 healthy negative control, 33 treatment naïve patients as positive control, 19 patients at week 4, 22 at week 12, and 19 at week 24 of treatment initiation and 21 responders and 11 nonresponders at the end of 48-week treatment protocol.
Serum candidate proteins were measured using ELISA and liver fibrosis was assessed by AST platelet ratio index (APRI).
Results.
CHC significantly increased activins and decreased follistatin compared to negative control (P<0.05).
Activin-A and follistatin levels returned to the levels of negative control group at weeks 4, 12, and 24 following treatment initiation and were significantly different from positive control (P<0.05).
Both proteins were significantly different between responders and nonresponders.
Activin-A correlated positively and significantly with the viral load and APRI.
Conclusion.
CHC modulates serum activin-A and follistatin and they appear to be influenced by pegylated interferon-α therapy.
Further studies are needed to explore the role of activins in CHC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Refaat, Bassem& El-Shemi, Adel Galal& Ashshi, Ahmed Mohamed& AlZanbagi, Adnan. 2014. Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes : A Preliminary Report. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Refaat, Bassem…[et al.]. Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes : A Preliminary Report. Gastroenterology Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-486415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Refaat, Bassem& El-Shemi, Adel Galal& Ashshi, Ahmed Mohamed& AlZanbagi, Adnan. Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes : A Preliminary Report. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر