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Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo
المؤلفون المشاركون
Cha, Ji Young
Ahn, Yong-Tae
Kim, Sang Chan
Jung, Ji Yun
Jung, Jae Yup
An, Won G.
Ku, Sae-Kwang
Lee, Jong Rok
Cho, Il Je
Byun, Sung Hui
Lee, Chul Won
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-06
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Pyungwi-san (PWS) is a traditional basic herbal formula.
We investigated the effects of PWS on induction of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), pro-inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)) and nuclear factor-kappa B (NF-κB) as well as mitogen-activated protein kinases (MAPKs) in lipopolysaccharide-(LPS-) induced Raw 264.7 cells and on paw edema in rats.
Treatment with PWS (0.5, 0.75, and 1 mg/mL) resulted in inhibited levels of expression of LPS-induced COX-2, iNOS, NF-κB, and MAPKs as well as production of prostaglandin E2 (PGE2), nitric oxide (NO), IL-6, and TNF-α induced by LPS.
Our results demonstrate that PWS possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-κB and MAPKs in LPS-induced macrophage cells.
More importantly, results of the carrageenan-(CA-) induced paw edema demonstrate an anti-edema effect of PWS.
In addition, it is considered that PWS also inhibits the acute edematous inflammations through suppression of mast cell degranulations and inflammatory mediators, including COX-2, iNOS and TNF-α.
Thus, our findings may provide scientific evidence to explain the anti-inflammatory properties of PWS in vitro and in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cha, Ji Young& Jung, Ji Yun& Jung, Jae Yup& Lee, Jong Rok& Cho, Il Je& Ku, Sae-Kwang…[et al.]. 2013. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-486535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cha, Ji Young…[et al.]. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-486535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cha, Ji Young& Jung, Ji Yun& Jung, Jae Yup& Lee, Jong Rok& Cho, Il Je& Ku, Sae-Kwang…[et al.]. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-486535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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