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Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes
المؤلفون المشاركون
Zaborowski, Mikolaj Piotr
Michalak, Slawomir
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Paraneoplastic neurological syndromes (PNS) are disorders of the nervous system that are associated with remote effects of malignancy.
PNS are considered to have an autoimmune pathology.
It has been suggested that immune antitumor responses are the origin of improved outcome in PNS.
We describe cell-mediated immune responses in PNS and their potential contributions to antitumor reactions.
Experimental and neuropathological studies have revealed infiltrates in nervous tissue and disturbances in lymphocyte populations in both cerebrospinal fluid and peripheral blood.
A predominance of cytotoxic T lymphocytes (CTLs) over T helper cells has been observed.
CTLs can be specifically aggressive against antigens shared by tumors and nervous tissue.
Based on genetic studies, a common clonal origin of lymphocytes from blood, tumor, and nervous tissue is suggested.
Suppressive regulatory T (Treg) lymphocytes are dysfunctional.
Simultaneously, in tumor tissue, more intense cell-mediated immune responses are observed, which often coincide with a less aggressive course of neoplastic disease.
An increased titer of onconeural antibodies is also related to better prognoses in patients without PNS.
The evaluation of onconeural and neuronal surface antibodies was recommended in current guidelines.
The link between PNS emergence and antitumor responses may result from more active CTLs and less functional Treg lymphocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zaborowski, Mikolaj Piotr& Michalak, Slawomir. 2013. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-486571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zaborowski, Mikolaj Piotr& Michalak, Slawomir. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-486571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zaborowski, Mikolaj Piotr& Michalak, Slawomir. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-486571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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