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Development of Cutaneous Leishmaniasis after Leishmania Skin Test
المؤلفون المشاركون
Machado, Paulo R.
Dantas, Marina L.
Arruda, Sérgio
Machado, Gustavo U.
Carvalho, Augusto M.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-24
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Thirty-year-old female with a previous history of a cutaneous ulcer suspicious of leishmaniasis 20 years ago presented with a new complaint of a depressed papular lesion 8×7 mm in the right lower extremity.
The lesion was of 10-day duration.
Because early cutaneous leishmaniasis (CL) lesions may have a non-ulcerated appearance, a Leishmania skin test (LST) was performed on the forearm with a strong positive result (38×32 mm).
After 8 days, the lesion in the leg, which was diagnosed as folliculitis, completely healed.
However, a typical CL ulcer (26×24 mm) developed at the LST site.
Histopathology of the new lesion did not identifiy parasites, but the findings were consistent with a diagnosis of CL.
Further analysis identified amastigotes by immunohistochemical stain.
Mononuclear cells harvested from the patient were stimulated with Leishmania antigen and showed high levels of production of both tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ): 2,943 pg/mL and 2,313 pg/mL, respectively.
After 40 days of treatment with antimony and pentoxifylline, the ulcer resolved.
The development of CL at the LST site suggests a strong Th1 immune response, and it is an in vivo documentation of the role of the host immune response in the pathology of CL.
It teaches us that LST should be cautiously, if at all, used in patients with self-healing CL ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Machado, Paulo R.& Carvalho, Augusto M.& Machado, Gustavo U.& Dantas, Marina L.& Arruda, Sérgio. 2011. Development of Cutaneous Leishmaniasis after Leishmania Skin Test. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-486626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Machado, Paulo R.…[et al.]. Development of Cutaneous Leishmaniasis after Leishmania Skin Test. Case Reports in Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-486626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Machado, Paulo R.& Carvalho, Augusto M.& Machado, Gustavo U.& Dantas, Marina L.& Arruda, Sérgio. Development of Cutaneous Leishmaniasis after Leishmania Skin Test. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-486626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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