MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors
المؤلفون المشاركون
Calcagno, Danielle Queiroz
Burbano, Rommel Rodríguez
de Arruda Cardoso Smith, Marília
Silva, Tanielly Cristina Raiol
Khayat, André Salim
Leal, Mariana Ferreira
Assumpção, Paulo Pimentel
Chen, Elizabeth Suchi
Borges da Costa, Joana de Fátima Ferreira
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We evaluated whether MYC, TP53, and chromosome 17 copy-number alterations occur in ACP02, ACP03, and AGP01 gastric cancer cell lines and in their tumor counterpart.
Fluorescence in situ hybridization for MYC and TP53 genes and for chromosome 17 was applied in the 6th, 12th, 60th, and 85th passages of the cell lines and in their parental primary tumors.
We observed that three and four MYC signals were the most common alterations in gastric cell lines and tumors.
ACP02 presented cells with two copies of chr17 and loss of one copy of TP53 more frequently than ACP03 and AGP01.
Only ACP03 and AGP01 presented clonal chr17 trisomy with three or two TP53 copies.
The frequency of MYC gain, TP53 loss, and chromosome 17 trisomy seems to increase in gastric cell lines compared to their parental tumors.
Our findings reveal that these cell lines retain, in vitro, the genetic alterations presented in their parental primary tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leal, Mariana Ferreira& Calcagno, Danielle Queiroz& Borges da Costa, Joana de Fátima Ferreira& Silva, Tanielly Cristina Raiol& Khayat, André Salim& Chen, Elizabeth Suchi…[et al.]. 2011. MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leal, Mariana Ferreira…[et al.]. MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-486636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leal, Mariana Ferreira& Calcagno, Danielle Queiroz& Borges da Costa, Joana de Fátima Ferreira& Silva, Tanielly Cristina Raiol& Khayat, André Salim& Chen, Elizabeth Suchi…[et al.]. MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر