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Analyzing Adherence to Prenatal Supplement : Does Pill Count Measure Up?
المؤلفون المشاركون
Hollis, Bruce W.
Nietert, Paul J.
Appelgren, Kristie E.
Hulsey, Thomas C.
Wagner, Carol L.
المصدر
International Journal of Endocrinology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-02-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To determine if adherence as measured by pill count would show a significant association with serum-based measures of adherence.
Methods.
Data were obtained from a prenatal vitamin D supplementation trial where subjects were stratified by race and randomized into three dosing groups: 400 (control), 2000, or 4000 IU vitamin D3/day.
One measurement of adherence was obtained via pill counts remaining compared to a novel definition for adherence using serum 25-hydroxy-vitamin D (25-OH-D) levels (absolute change in 25(OH)D over the study period and the subject's steady-state variation in their 25(OH)D levels).
A multivariate logistic regression model examined whether mean percent adherence by pill count was significantly associated with the adherence measure by serum metabolite levels.
Results.
Subjects' mean percentage of adherence by pill count was not a significant predictor of adherence by serum metabolite levels.
This finding was robust across a series of sensitivity analyses.
Conclusions.
Based on our novel definition of adherence, pill count was not a reliable predictor of adherence to protocol, and calls into question how adherence is measured in clinical research.
Our findings have implications regarding the determination of efficacy of medications under study and offer an alternative approach to measuring adherence of long half-life supplements/medications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Appelgren, Kristie E.& Nietert, Paul J.& Hulsey, Thomas C.& Hollis, Bruce W.& Wagner, Carol L.. 2010. Analyzing Adherence to Prenatal Supplement : Does Pill Count Measure Up?. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-486708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Appelgren, Kristie E.…[et al.]. Analyzing Adherence to Prenatal Supplement : Does Pill Count Measure Up?. International Journal of Endocrinology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-486708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Appelgren, Kristie E.& Nietert, Paul J.& Hulsey, Thomas C.& Hollis, Bruce W.& Wagner, Carol L.. Analyzing Adherence to Prenatal Supplement : Does Pill Count Measure Up?. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-486708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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