Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging
المؤلفون المشاركون
Chorilli, Marlus
Sato, Claudia S.
Friberg, Stig E.
Prado, Alice Haddad do
Oliveira, Marcela B.
Lourenço Brunetti, Iguatemy
Bernegossi, Jéssica
Leonardi, Gislaine Ricci
Scarpa, Maria Virgínia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP).
LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLSv = RP-loaded opaque liquid system and TLSv = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied.
Samples were characterized using polarized light microscopy (PLM) and rheology analysis.
In vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays.
In vitro antioxidant activity was performed by the DPPH method.
PLM analysis showed the presence of lamellar LCS just to TLS.
Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations.
The results showed that the incorporation of RP in LCS improved the safety profile of the drug.
In vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP.
PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Marcela B.& Prado, Alice Haddad do& Bernegossi, Jéssica& Sato, Claudia S.& Lourenço Brunetti, Iguatemy& Scarpa, Maria Virgínia…[et al.]. 2014. Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486767
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Marcela B.…[et al.]. Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-486767
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Marcela B.& Prado, Alice Haddad do& Bernegossi, Jéssica& Sato, Claudia S.& Lourenço Brunetti, Iguatemy& Scarpa, Maria Virgínia…[et al.]. Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486767
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486767
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر