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Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats
المؤلفون المشاركون
Macarini, José Roberto
Streck, Emilio Luiz
Bogo, Maurício Reis
Ferreira, Gustavo Costa
Dimer, Nádia Webber
Maravai, Soliany Grassi
Gonçalves, Cinara Ludvig
Schuck, Patrícia Fernanda
Kist, Luiza Wilges
Cararo, José Henrique
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Serum carnosinase deficiency is an inherited disorder that leads to an accumulation of carnosine in the brain tissue, cerebrospinal fluid, skeletal muscle, and other tissues of affected patients.
Considering that high levels of carnosine are associated with neurological dysfunction and that the pathophysiological mechanisms involved in serum carnosinase deficiency remain poorly understood, we investigated the in vivo effects of carnosine on bioenergetics parameters, namely, respiratory chain complexes (I–III, II, and II-III), malate dehydrogenase, succinate dehydrogenase, and creatine kinase activities and the expression of mitochondrial-specific transcription factors (NRF-1, PGC-1α, and TFAM) in skeletal muscle of young Wistar rats.
We observed a significant decrease of complexes I–III and II activities in animals receiving carnosine acutely, as compared to control group.
However, no significant alterations in respiratory chain complexes, citric acid cycle enzymes, and creatine kinase activities were found between rats receiving carnosine chronically and control group animals.
As compared to control group, mRNA levels of NRF-1, PGC-1α, and TFAM were unchanged.
The present findings indicate that electron transfer through the respiratory chain is impaired in skeletal muscle of rats receiving carnosine acutely.
In case these findings are confirmed by further studies and ATP depletion is also observed, impairment of bioenergetics could be considered a putative mechanism responsible for the muscle damage observed in serum carnosinase-deficient patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Macarini, José Roberto& Maravai, Soliany Grassi& Cararo, José Henrique& Dimer, Nádia Webber& Gonçalves, Cinara Ludvig& Kist, Luiza Wilges…[et al.]. 2014. Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-486812
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Macarini, José Roberto…[et al.]. Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-486812
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Macarini, José Roberto& Maravai, Soliany Grassi& Cararo, José Henrique& Dimer, Nádia Webber& Gonçalves, Cinara Ludvig& Kist, Luiza Wilges…[et al.]. Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-486812
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486812
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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