![](/images/graphics-bg.png)
Role of Bone Marrow-Derived MonocytesMacrophages in the Repair of Mucosal Damage Caused by Irradiation andor Anticancer Drugs in Colitis Model
المؤلفون المشاركون
Kasahara, Tadashi
Takaba, Junji
Mishima, Yuji
Hatake, Kiyohiko
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mucosal damage is a common side effect of many cancer treatments, especially radiotherapy and intensive chemotherapy, which often induce bone marrow (BM) suppression.
We observed that acetic acid- (AA-) induced mucosal damage in the colon of mice was worsened by simultaneous treatment with irradiation or 5-FU.
However, irradiation 14 days prior to the AA treatment augmented the recovery from mucosal damage, suggesting that the recovery from BM suppression had an advantageous effect on the mucosal repair.
In addition, BM transplantation also augmented the recovery from AA-induced mucosal damage.
We further confirmed that transplanted BM-derived cells, particularly F4/80+Gr1+ “inflammatory” monocytes (Subset 1), accumulated in the damaged mucosal area in the early healing phase, and both of Subset 1 and F4/80+Gr1- “resident” monocytes (Subset 2) accumulated in this area in later phases.
Our results suggest that monocytes/macrophages contribute to the mucosal recovery and regeneration following mucosal damage by anticancer drug therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takaba, Junji& Mishima, Yuji& Hatake, Kiyohiko& Kasahara, Tadashi. 2011. Role of Bone Marrow-Derived MonocytesMacrophages in the Repair of Mucosal Damage Caused by Irradiation andor Anticancer Drugs in Colitis Model. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-486825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takaba, Junji…[et al.]. Role of Bone Marrow-Derived MonocytesMacrophages in the Repair of Mucosal Damage Caused by Irradiation andor Anticancer Drugs in Colitis Model. Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-486825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takaba, Junji& Mishima, Yuji& Hatake, Kiyohiko& Kasahara, Tadashi. Role of Bone Marrow-Derived MonocytesMacrophages in the Repair of Mucosal Damage Caused by Irradiation andor Anticancer Drugs in Colitis Model. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-486825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)