Role of Vitamin D in Insulin Resistance
المؤلفون المشاركون
Liao, Min-Tser
Wu, Chia-Chao
Lu, Kuo-Cheng
Sung, Chih-Chien
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Vitamin D is characterized as a regulator of homeostasis of bone and mineral metabolism, but it can also provide nonskeletal actions because vitamin D receptors have been found in various tissues including the brain, prostate, breast, colon, pancreas, and immune cells.
Bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation are all biological functions of vitamin D.
Vitamin D may play an important role in modifying the risk of cardiometabolic outcomes, including diabetes mellitus (DM), hypertension, and cardiovascular disease.
The incidence of type 2 DM is increasing worldwide and results from a lack of insulin or inadequate insulin secretion following increases in insulin resistance.
Therefore, it has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes.
The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1alpha-hydroxylase gene.
Other roles have been proposed to involve immunoregulatory function by activating innate and adaptive immunity and cytokine release, activating inflammation by upregulation of nuclear factor κB and inducing tumor necrosis factor α, and other molecular actions to maintain glucose homeostasis and mediate insulin sensitivity by a low calcium status, obesity, or by elevating serum levels of parathyroid hormone.
These effects of vitamin D deficiency, either acting in concert or alone, all serve to increase insulin resistance.
Although there is evidence to support a relationship between vitamin D status and insulin resistance, the underlying mechanism requires further exploration.
The purpose of this paper was to review the current information available concerning the role of vitamin D in insulin resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sung, Chih-Chien& Liao, Min-Tser& Lu, Kuo-Cheng& Wu, Chia-Chao. 2012. Role of Vitamin D in Insulin Resistance. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-486834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sung, Chih-Chien…[et al.]. Role of Vitamin D in Insulin Resistance. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-486834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sung, Chih-Chien& Liao, Min-Tser& Lu, Kuo-Cheng& Wu, Chia-Chao. Role of Vitamin D in Insulin Resistance. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-486834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر