Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid β(1-42), Tau, and Phosphorylated Tau in Alzheimer's Disease : Report of an International Workshop
المؤلفون المشاركون
van Uffelen, Kees
Teunissen, Charlotte E.
Blankenstein, Marinus A.
Verwey, Niek A.
Kester, Maartje I.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Large variation in assay performance and outcomes of CSF Aβ1-42, total Tau (Tau), and phosphorylated Tau (pTau) (at amino acid 181) levels is observed between laboratories.
The aim of this study was to assess the differences in assay procedures between several experienced international laboratories, as potential sources of error.
14 groups performed the Aβ42, Tau, and pTau assays according to the guidelines of the manufacturer.
Differences in analytical procedures between the laboratories were monitored.
At least 23 items in assay procedures were identified that varied between the laboratories, including procedures for washing, pipetting, incubation, finishing, and sample handing.
In general, the inter- and intra-assay variation between the groups was generally below 10% for all three assays.
We concluded that 17 international centers that use the same assays for Aβ42, Tau and pTau on a regular basis do not uniformly adhere to the procedures recommended by the manufacturer.
For harmonization of intercenter results of these biomarkers standardization of protocols is highly needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teunissen, Charlotte E.& Verwey, Niek A.& Kester, Maartje I.& van Uffelen, Kees& Blankenstein, Marinus A.. 2010. Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid β(1-42), Tau, and Phosphorylated Tau in Alzheimer's Disease : Report of an International Workshop. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-486913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teunissen, Charlotte E.…[et al.]. Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid β(1-42), Tau, and Phosphorylated Tau in Alzheimer's Disease : Report of an International Workshop. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-486913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teunissen, Charlotte E.& Verwey, Niek A.& Kester, Maartje I.& van Uffelen, Kees& Blankenstein, Marinus A.. Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid β(1-42), Tau, and Phosphorylated Tau in Alzheimer's Disease : Report of an International Workshop. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-486913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-486913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر