Interplay of T Helper 17 Cells with CD4+CD25high FOXP3+ Tregs in Regulation of Allergic Asthma in Pediatric Patients
المؤلفون المشاركون
Chauhan, Anil
Chatterjee, B. P.
Singh, Meenu
Chakraborti, Anuradha
Agarwal, Amit
المصدر
International Journal of Pediatrics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
There is evidence that Tregs are important to prevent allergic diseases like asthma but limited literature exists on role of TH17 cells in allergic diseases.
Methods.
Fifty children with asthma and respiratory allergy (study group) and twenty healthy children (control group) were recruited in this study.
Total IgE levels and pulmonary function tests were assessed.
The expression of Tregs and cytokines was determined by flow cytometry.
Results.
The average level of total IgE in study group (316.8 ± 189.8 IU/mL) was significantly higher than controls (50 ± 17.5 IU/mL, P<0.0001).
The frequency of TH17 cells and culture supernatant level of IL-17 in study group (12.09 ± 8.67 pg/mL) was significantly higher than control group (2.01 ± 1.27 pg/mL, P<0.001).
Alternatively, the frequency of FOXP3 level was significantly lower in study group [(49.00 ± 13.47)%] than in control group [(95.91 ± 2.63)%] and CD4+CD25+FOXP3+ to CD4+CD25+ ratio was also significantly decreased in study group [(6.33 ± 2.18)%] compared to control group [(38.61 ± 11.04)%].
The total serum IgE level is negatively correlated with FOXP3 level (r=-0.5273, P<0.0001).
The FOXP3 expression is negatively correlated with the IL-17 levels (r=-0.5631, P<0.0001) and IL-4 levels (r=-0.2836, P=0.0460).
Conclusions.
Imbalance in TH17/Tregs, elevated IL-17, and IL-4 response and downregulation of FOXP3 were associated with allergic asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Agarwal, Amit& Singh, Meenu& Chatterjee, B. P.& Chauhan, Anil& Chakraborti, Anuradha. 2014. Interplay of T Helper 17 Cells with CD4+CD25high FOXP3+ Tregs in Regulation of Allergic Asthma in Pediatric Patients. International Journal of Pediatrics،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Agarwal, Amit…[et al.]. Interplay of T Helper 17 Cells with CD4+CD25high FOXP3+ Tregs in Regulation of Allergic Asthma in Pediatric Patients. International Journal of Pediatrics No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-487032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Agarwal, Amit& Singh, Meenu& Chatterjee, B. P.& Chauhan, Anil& Chakraborti, Anuradha. Interplay of T Helper 17 Cells with CD4+CD25high FOXP3+ Tregs in Regulation of Allergic Asthma in Pediatric Patients. International Journal of Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر