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Long-Term Effects of Maternal Deprivation on Cholinergic System in Rat Brain
المؤلفون المشاركون
Filipović, Branislav
Radonjić, Nevena V.
Marković, Branka
Petronijević, Nataša
Aksić, Milan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Numerous clinical studies have demonstrated an association between early stressful life events and adult life psychiatric disorders including schizophrenia.
In rodents, early life exposure to stressors such as maternal deprivation (MD) produces numerous hormonal, neurochemical, and behavioral changes and is accepted as one of the animal models of schizophrenia.
The stress induces acetylcholine (Ach) release in the forebrain and the alterations in cholinergic neurotransmitter system are reported in schizophrenia.
The aim of this study was to examine long-term effects of maternal separation on acetylcholinesterase (AChE) activity in different brain structures and the density of cholinergic fibers in hippocampus and retrosplenial (RS) cortex.
Wistar rats were separated from their mothers on the postnatal day (P) 9 for 24 h and sacrificed on P60.
Control group of rats was bred under the same conditions, but without MD.
Brain regions were collected for AChE activity measurements and morphometric analysis.
Obtained results showed significant decrease of the AChE activity in cortex and increase in the hippocampus of MD rats.
Density of cholinergic fibers was significantly increased in CA1 region of hippocampus and decreased in RS cortex.
Our results indicate that MD causes long-term structure specific changes in the cholinergic system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marković, Branka& Radonjić, Nevena V.& Aksić, Milan& Filipović, Branislav& Petronijević, Nataša. 2014. Long-Term Effects of Maternal Deprivation on Cholinergic System in Rat Brain. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marković, Branka…[et al.]. Long-Term Effects of Maternal Deprivation on Cholinergic System in Rat Brain. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-487061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marković, Branka& Radonjić, Nevena V.& Aksić, Milan& Filipović, Branislav& Petronijević, Nataša. Long-Term Effects of Maternal Deprivation on Cholinergic System in Rat Brain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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