TNF-Alpha in the Locomotor System beyond Joints : High Degree of Involvement in Myositis in a Rabbit Model
المؤلفون المشاركون
Renström, Lina
Gaida, James E.
Forsgren, Sture
Purdam, Craig
المصدر
International Journal of Rheumatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The importance of TNF-alpha in arthritis is well documented.
It may be that TNF-alpha is also markedly involved in muscle inflammation (myositis).
An animal model where this can be investigated is needed.
A newly developed rabbit myositis model involving pronounced muscle overuse and local injections of substances having proinflammatory effects was therefore used in the present study.
The aim was to investigate the patterns of TNF-alpha expression in the developing myositis and to evaluate the usefulness of this myositis model for further TNF-alpha research.
Human rheumatoid arthritis (RA) synovial tissue was examined as a reference.
TNF-alpha immunoexpression and TNF-alpha mRNA, visualized via in situ hybridization, were detected in cells in the inflammatory infiltrates of the affected muscle (soleus muscle).
Coexistence of TNF-alpha and CD68 immunoreactions was noted, suggesting that the TNF-alpha reactive cells are macrophages.
Expression of TNF-alpha mRNA was also noted in muscle fibers and blood vessel walls in areas with inflammation.
These findings demonstrate that TNF-alpha is highly involved in the myositis process.
The model can be used in further studies evaluating the importance of TNF-alpha in developing myositis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Forsgren, Sture& Renström, Lina& Purdam, Craig& Gaida, James E.. 2012. TNF-Alpha in the Locomotor System beyond Joints : High Degree of Involvement in Myositis in a Rabbit Model. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-487138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Forsgren, Sture…[et al.]. TNF-Alpha in the Locomotor System beyond Joints : High Degree of Involvement in Myositis in a Rabbit Model. International Journal of Rheumatology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-487138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Forsgren, Sture& Renström, Lina& Purdam, Craig& Gaida, James E.. TNF-Alpha in the Locomotor System beyond Joints : High Degree of Involvement in Myositis in a Rabbit Model. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-487138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر