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Concave Urinary Crystallines : Direct Evidence of Calcium Oxalate Crystals Dissolution by Citrate In Vivo
المؤلفون المشاركون
Ouyang, Jian-Ming
Xu, Meng
Zhang, Guang-Na
Shang, Yun-Feng
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The changes in urinary crystal properties in patients with calcium oxalate (CaOx) calculi after oral administration of potassium citrate (K3cit) were investigated via atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray powder diffractometry (XRD), and zeta potential analyzer.
The AFM and SEM results showed that the surface of urinary crystals became concave, the edges and corners of crystals became blunt, the average size of urinary crystallines decreased significantly, and aggregation of urinary crystals was reduced.
These changes were attributed to the significant increase in concentration of excreted citrate to 492±118 mg/L after K3cit intake from 289±83 mg/L before K3cit intake.
After the amount of urinary citrate was increased, it complexed with Ca2+ ions on urinary crystals, which dissolved these crystals.
Thus, the appearance of concave urinary crystals was a direct evidence of CaOx dissolution by citrate in vivo.
The XRD results showed that the quantities and species of urinary crystals decreased after K3cit intake.
The mechanism of inhibition of formation of CaOx stones by K3cit was possibly due to the complexation of Ca2+ with citrate, increase in urine pH, concentration of urinary inhibitor glycosaminoglycans (GAGs), and the absolute value of zeta potential after K3cit intake.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shang, Yun-Feng& Xu, Meng& Zhang, Guang-Na& Ouyang, Jian-Ming. 2013. Concave Urinary Crystallines : Direct Evidence of Calcium Oxalate Crystals Dissolution by Citrate In Vivo. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shang, Yun-Feng…[et al.]. Concave Urinary Crystallines : Direct Evidence of Calcium Oxalate Crystals Dissolution by Citrate In Vivo. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-487153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shang, Yun-Feng& Xu, Meng& Zhang, Guang-Na& Ouyang, Jian-Ming. Concave Urinary Crystallines : Direct Evidence of Calcium Oxalate Crystals Dissolution by Citrate In Vivo. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-487153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487153
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