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Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy
المؤلفون المشاركون
Tipoe, George L.
Xiao, Jia
Chang, Raymond Chuen Chung
Guo, Rui
Ching, Yick-Pang
Fung, Man-Lung
Liong, Emily C.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Our previous study demonstrated that administration of garlic-derived antioxidant S-allylmercaptocysteine (SAMC) ameliorated hepatic injury in a nonalcoholic fatty liver disease (NAFLD) rat model.
Our present study aimed to investigate the mechanism of SAMC on NAFLD-induced hepatic apoptosis and autophagy.
Adult female rats were fed with a high-fat diet for 8 weeks to develop NAFLD with or without intraperitoneal injection of 200 mg/kg SAMC for three times per week.
During NAFLD development, increased apoptotic cells and caspase-3 activation were observed in the liver.
Increased apoptosis was modulated through both intrinsic and extrinsic apoptotic pathways.
NAFLD treatment also enhanced the expression of key autophagic markers in the liver with reduced activity of LKB1/AMPK and PI3K/Akt pathways.
Increased expression of proapoptotic regulator p53 and decreased activity of antiautophagic regulator mTOR were also observed.
Administration of SAMC reduced the number of apoptotic cells through downregulation of both intrinsic and extrinsic apoptotic mechanisms.
SAMC also counteracted the effects of NAFLD on LKB1/AMPK and PI3K/Akt pathways.
Treatment with SAMC further enhanced hepatic autophagy by regulating autophagic markers and mTOR activity.
In conclusion, administration of SAMC during NAFLD development in rats protects the liver from chronic injury by reducing apoptosis and enhancing autophagy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiao, Jia& Guo, Rui& Fung, Man-Lung& Liong, Emily C.& Chang, Raymond Chuen Chung& Ching, Yick-Pang…[et al.]. 2013. Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-487638
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiao, Jia…[et al.]. Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-487638
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiao, Jia& Guo, Rui& Fung, Man-Lung& Liong, Emily C.& Chang, Raymond Chuen Chung& Ching, Yick-Pang…[et al.]. Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-487638
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487638
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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