Glycoprotein IIbIIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction
المؤلفون المشاركون
Rathod, K.
Knight, C.
Wragg, A.
Mathur, A.
Antoniou, S.
Wright, P.
Howard, J. P.
Jones, D. A.
Gallagher, S.
Weerackody, R.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
We investigate the effect of glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors on long-term outcomes following percutaneous coronary intervention (PCI) after non-ST elevation myocardial infarction (NSTEMI).
Meta-analyses indicate that these agents are associated with improved short-term outcomes.
However, many trials were undertaken before the routine use of P2Y12 inhibitors.
Recent studies yield conflicting results and registry data have suggested that GP IIb/IIIa inhibitors may cause more bleeding than what trials indicate.
Methods and Results.
This retrospective observational study involves 3047 patients receiving dual-antiplatelet therapy who underwent PCI for NSTEMI.
Primary outcome was all-cause mortality.
Major adverse cardiac events (MACE) were a secondary outcome.
Mean follow-up was 4.6 years.
Patients treated with GP IIb/IIIa inhibitors were younger with fewer comorbidities.
Although the unadjusted Kaplan-Meier analysis suggested that GP IIb/IIIa inhibitor use was associated with improved outcomes, multivariate analysis (including propensity scoring) showed no benefit for either survival (P=0.136) or MACE (P=0.614).
GP IIb/IIIa inhibitor use was associated with an increased risk of major bleeding (P=0.021).
Conclusion.
Although GP IIb/IIIa inhibitor use appeared to improve outcomes after PCI for NSTEMI, patients who received GP IIb/IIIa inhibitors tended to be at lower risk.
After multivariate adjustment we observed no improvement in MACE or survival and an increased risk of major bleeding.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Howard, J. P.& Jones, D. A.& Gallagher, S.& Rathod, K.& Antoniou, S.& Wright, P.…[et al.]. 2014. Glycoprotein IIbIIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487734
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Howard, J. P.…[et al.]. Glycoprotein IIbIIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-487734
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Howard, J. P.& Jones, D. A.& Gallagher, S.& Rathod, K.& Antoniou, S.& Wright, P.…[et al.]. Glycoprotein IIbIIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487734
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487734
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر