Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm

المؤلفون المشاركون

Yoshimura, Koichi
Aoki, Hiroki

المصدر

International Journal of Vascular Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-08-21

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Abdominal aortic aneurysm (AAA) is a common disease causing segmental expansion and rupture of the aorta with a high mortality rate.

The lack of nonsurgical treatment represents a large and unmet need in terms of pharmacotherapy.

Advances in AAA research revealed that activation of inflammatory signaling pathways through proinflammatory mediators shifts the balance of extracellular matrix (ECM) metabolism toward tissue degradation.

This idea is supported by experimental evidence in animal models that pharmacologic intervention at each pathological step can prevent AAA development.

Previously, we identified c-Jun N-terminal kinase (JNK), a pro-inflammatory signaling molecule, as a therapeutic target for AAA.

Abnormal activation of JNK in AAA tissue regulates multiple pathological processes in a coordinated manner.

Pharmacologic inhibition of JNK tips the ECM balance back towards repair rather than degradation.

Interventions targeting signaling molecules such as JNK in order to manipulate multiple pathological processes may be an ideal therapeutic strategy for AAA.

Furthermore, the development of biomarkers as well as appropriate drug delivery systems is essential to produce clinically practical pharmacotherapy for AAA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yoshimura, Koichi& Aoki, Hiroki. 2012. Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-488006

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yoshimura, Koichi& Aoki, Hiroki. Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm. International Journal of Vascular Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-488006

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yoshimura, Koichi& Aoki, Hiroki. Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-488006

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-488006