Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection : Implications to Microbial Antibiotics Resistance
المؤلفون المشاركون
Ling, Maurice H. T.
Castillo, Clarence F. G.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Antibiotics resistance is a serious biomedical issue as formally susceptible organisms gain resistance under its selective pressure.
There have been contradictory results regarding the prevalence of resistance following withdrawal and disuse of the specific antibiotics.
Here, we use experimental evolution in “digital organisms” to examine the rate of gain and loss of resistance under the assumption that there is no fitness cost for maintaining resistance.
Our results show that selective pressure is likely to result in maximum resistance with respect to the selective pressure.
During deselection as a result of disuse of the specific antibiotics, a large initial loss and prolonged stabilization of resistance are observed, but resistance is not lost to the stage of preselection.
This suggests that a pool of partial persists organisms persist long after withdrawal of selective pressure at a relatively constant proportion.
Hence, contradictory results regarding the prevalence of resistance following withdrawal and disuse of the specific antibiotics may be a statistical variation about constant proportion.
Our results also show that subsequent reintroduction of the same selective pressure results in rapid regain of maximal resistance.
Thus, our simulation results suggest that complete elimination of specific antibiotics resistance is unlikely after the disuse of antibiotics once a resistant pool of microorganisms has been established.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castillo, Clarence F. G.& Ling, Maurice H. T.. 2014. Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection : Implications to Microbial Antibiotics Resistance. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-488023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castillo, Clarence F. G.& Ling, Maurice H. T.. Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection : Implications to Microbial Antibiotics Resistance. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-488023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castillo, Clarence F. G.& Ling, Maurice H. T.. Resistant Traits in Digital Organisms Do Not Revert Preselection Status despite Extended Deselection : Implications to Microbial Antibiotics Resistance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-488023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر