Effect of Mesalamine and Prednisolone on TNBS Experimental Colitis, following Various Doses of Orally Administered Iron
المؤلفون المشاركون
Gikas, Aristofanis
Triantafillidis, John K.
Douvi, Georgia
Patsouris, Efstratios
Agrogiannis, George
Papalois, Apostolos E.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Experimental data suggest that oral iron (I.) supplementation can worsen colitis in animals.
Aim.
To investigate the influence of various concentrations of orally administered I.
in normal gut mucosa and mucosa of animals with TNBS colitis, as well as the influence of Mesalamine (M.) and Prednisolone (P.) on the severity of TNBS colitis following orally administered I.
Methods and Materials.
156 Wistar rats were allocated into 10 groups.
Colitis was induced by TNBS.
On the 8th day, all animals were euthanatized.
Activity of colitis and extent of tissue damage were assessed histologically.
The levels of tissue tumor necrosis factor-α (t-TNF-α) and tissue malondialdehyde (t-MDA) were estimated in all animal groups.
Results.
Moderate and high I.
supplementation induced inflammation in the healthy colon and increased the activity of the experimentally induced TNBS colitis.
Administration of M.
on TNBS colitis following moderate iron supplementation (0.3 g/Kg diet) resulted in a significant improvement in the overall histological score as well as in two individual histological parameters.
M.
administration, however, did not significantly reduce the t-TNF-α levels (17.67±4.92 versus 14.58±5.71, P=0.102), although it significantly reduced the t-MDA levels (5.79±1.55 versus 3.67±1.39, P=0.000).
Administration of M.
on TNBS colitis following high iron supplementation (3.0 g/Kg diet) did not improve the overall histological score and the individual histological parameters, neither reduced the levels of t-TNF-α (16.57 ± 5.61 versus 14.65±3.88, P=0.296).
However, M.
significantly reduced the t-MDA levels (5.99±1.37 versus 4.04±1.41, P=0.000).
Administration of P.
on TNBS colitis after moderate iron supplementation resulted in a significant improvement in the overall histological score as well as in three individual histological parameters.
P.
also resulted in a significant reduction in the t-TNF-α levels (17.67±4.92 versus 12.64±3.97, P=0.003) and the t-MDA levels (5.79±1.54 versus 3.47±1.21, P=0.001).
Administration of P on TNBS colitis after high I.
supplementation resulted in a significant improvement of the overall histological score and three individual histological parameters and significantly reduced the levels of t-TNF-α (16.6±5.6 versus 11.85±1.3, P=0.001).
Conclusion.
I.
can induce colonic inflammation and aggravate TNBS colitis.
M.
and P.
can significantly improve the inflammatory process in the colonic mucosa in TNBS colitis aggravated by orally administered I.
P.
has a stable anti-TNF-α effect.
These findings suggest that the harmful.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Triantafillidis, John K.& Douvi, Georgia& Agrogiannis, George& Patsouris, Efstratios& Gikas, Aristofanis& Papalois, Apostolos E.. 2014. Effect of Mesalamine and Prednisolone on TNBS Experimental Colitis, following Various Doses of Orally Administered Iron. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488044
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Triantafillidis, John K.…[et al.]. Effect of Mesalamine and Prednisolone on TNBS Experimental Colitis, following Various Doses of Orally Administered Iron. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-488044
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Triantafillidis, John K.& Douvi, Georgia& Agrogiannis, George& Patsouris, Efstratios& Gikas, Aristofanis& Papalois, Apostolos E.. Effect of Mesalamine and Prednisolone on TNBS Experimental Colitis, following Various Doses of Orally Administered Iron. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488044
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488044
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر