Antibiofilm Activity, Compound Characterization, and Acute Toxicity of Extract from a Novel Bacterial Species of Paenibacillus
المؤلفون المشاركون
Omar, Rahmat
Yusof, Mohd Yasim
Alasil, Saad Musbah
Ismail, Salmah
المصدر
International Journal of Microbiology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
الملخص EN
The effectiveness of many antimicrobial agents is currently decreasing; therefore, it is important to search for alternative therapeutics.
Our study was carried out to assess the in vitro antibiofilm activity using microtiter plate assay, to characterize the bioactive compounds using Ultra Performance Liquid Chromatography-Diode Array Detection and Liquid Chromatography-Mass Spectrometry and to test the oral acute toxicity on Sprague Dawley rats of extract derived from a novel bacterial species of Paenibacillus strain 139SI.
Our results indicate that the crude extract and its three identified compounds exhibit strong antibiofilm activity against a broad range of clinically important pathogens.
Three potential compounds were identified including an amino acid antibiotic C8H20N3O4P (MW 253.237), phospholipase A2 inhibitor C21H36O5 (MW 368.512), and an antibacterial agent C14H11N3O2 (MW 253.260).
The acute toxicity test indicates that the mortality rate among all rats was low and that the biochemical parameters, hematological profile, and histopathology examination of liver and kidneys showed no significant differences between experimental groups P>0.05.
Overall, our findings suggest that the extract and its purified compounds derived from novel Paenibacillus sp.
are nontoxic exhibiting strong antibiofilm activity against Gram-positive and Gram-negative pathogens that can be useful towards new therapeutic management of biofilm-associated infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alasil, Saad Musbah& Omar, Rahmat& Ismail, Salmah& Yusof, Mohd Yasim. 2014. Antibiofilm Activity, Compound Characterization, and Acute Toxicity of Extract from a Novel Bacterial Species of Paenibacillus. International Journal of Microbiology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-488129
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alasil, Saad Musbah…[et al.]. Antibiofilm Activity, Compound Characterization, and Acute Toxicity of Extract from a Novel Bacterial Species of Paenibacillus. International Journal of Microbiology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-488129
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alasil, Saad Musbah& Omar, Rahmat& Ismail, Salmah& Yusof, Mohd Yasim. Antibiofilm Activity, Compound Characterization, and Acute Toxicity of Extract from a Novel Bacterial Species of Paenibacillus. International Journal of Microbiology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-488129
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488129
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر