Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus
المؤلفون المشاركون
Chang, Shih-Liang
Lin, Jaung-Geng
Lee, Yu-Chen
Ho, Wai-Jane
Chen, Ying-I
Tzeng, Chung-Yuh
Li, Te-Mao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes.
However, whether EA reduces plasma glucose levels in type I diabetes is still unknown.
In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose.
Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats.
EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1 i.p.), Eserine (0.01 mg kg−1 i.p.), or Hemicholinium-3 (5 μg kg−1 i.p.) in non-adrenalectomized rats.
Rats administered acetylcholine (0.01 mg kg−1 i.v.) did not undergo EA.
Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment.
Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels.
Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot.
Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response.
In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels.
In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response.
EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins.
Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Yu-Chen& Li, Te-Mao& Tzeng, Chung-Yuh& Chen, Ying-I& Ho, Wai-Jane& Lin, Jaung-Geng…[et al.]. 2011. Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-488206
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Yu-Chen…[et al.]. Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-488206
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Yu-Chen& Li, Te-Mao& Tzeng, Chung-Yuh& Chen, Ying-I& Ho, Wai-Jane& Lin, Jaung-Geng…[et al.]. Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-488206
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488206
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر