Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus

المؤلفون المشاركون

Škrha, J.
Kalousová, M.
Zima, T.
Loni Ekali, G.
Prázný, Martin
Kvasnička, Jan
Šoupal, Jan
Škrha, Jan
Landová, L.

المصدر

Journal of Diabetes Research

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-03-10

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

The aim of this study was to compare skin autofluorescence caused by advanced glycation end-products (AGEs) with biochemical markers of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in patients with diabetes.

Skin autofluorescence (AF) assessed by AGE-Reader was evaluated with sRAGE and other biochemical parameters in 88 patients with diabetes (47 Type 1/T1DM/ and 41 Type 2/T2DM/) and 20 controls.

Skin AF was significantly higher in T1DM and T2DM in comparison to controls (2.39 ± 0.54, 2.63 ± 0.73 versus 1.96 ± 0.33 AU; P<0.0001).

Positive correlation of AF with sRAGE was detected in T1DM and T2DM (r=0.37, P<0.02 and r=0.60, P<0.0001), but not in controls.

Significantly higher AF values were found in patients with positive albuminuria as compared to those with normal albuminuria.

Similarly, higher AF was detected in patients with endothelial dysfunction expressed by vWF, ICAM-1, and VCAM-1.

Multiple regression analysis revealed independent association of skin AF with age, sRAGE, and albumin-creatinine ratio in patients with diabetes (R2=0.38).

Our study confirms that AF is elevated in patients with diabetes, especially with positive albuminuria and endothelial dysfunction.

The strong and independent relationship between AF and sRAGE supports the idea that AF may reflect AGEs/RAGE interactions.

The exact mechanism remains to be established.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Škrha, J.& Šoupal, Jan& Loni Ekali, G.& Prázný, Martin& Kalousová, M.& Kvasnička, Jan…[et al.]. 2013. Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488241

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Škrha, J.…[et al.]. Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus. Journal of Diabetes Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-488241

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Škrha, J.& Šoupal, Jan& Loni Ekali, G.& Prázný, Martin& Kalousová, M.& Kvasnička, Jan…[et al.]. Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488241

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-488241