Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wntβ-Catenin-BMP Signaling
المؤلفون المشاركون
Shi, Qi
Wang, Yong-Jun
Holz, Jonathan
Zhao, Yong-Jian
Wang, Jing
Li, Xiao-Feng
Xu, Hao
Tang, De-Zhi
Cheng, Shao-Dan
Xu, Guo-Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Icariin has been mostly reported to enhance bone fracture healing and treat postmenopausal osteoporosis in ovariectomized animal model.
As another novel animal model of osteoporosis, there is few publication about the effect of Icariin on osteoprotegerin-deficient mice.
Therefore, the goal of this study is to find the effect on bone formation and underlying mechanisms of Icariin in osteoprotegerin (OPG) knockout (KO) mice.
We found that Icariin significantly stimulated new bone formation after local injection over the surface of calvaria at the dose of 5 mg/kg per day.
With this dose, Icariin was also capable of significantly reversing OPG-deficient-induced bone loss and bone strength reduction.
Real-time PCR analysis showed that Icariin significantly upregulated the expression of BMP2, BMP4, RUNX2, OC, Wnt1, and Wnt3a in OPG KO mice.
Icariin also significantly increased the expression of AXIN2, DKK1, TCF1, and LEF1, which are the direct target genes of β-catenin signaling.
The in vitro studies showed that Icariin induced osteoblast differentiation through the activation of Wnt/β-catenin-BMP signaling by in vitro deletion of the β-catenin gene using β-cateninfx/fx mice.
Together, our findings demonstrate that Icariin significantly reverses the phenotypes of OPG-deficient mice through the activation of Wnt/β-catenin-BMP signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao-Feng& Xu, Hao& Zhao, Yong-Jian& Tang, De-Zhi& Xu, Guo-Hua& Holz, Jonathan…[et al.]. 2013. Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wntβ-Catenin-BMP Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-488411
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao-Feng…[et al.]. Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wntβ-Catenin-BMP Signaling. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-488411
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao-Feng& Xu, Hao& Zhao, Yong-Jian& Tang, De-Zhi& Xu, Guo-Hua& Holz, Jonathan…[et al.]. Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wntβ-Catenin-BMP Signaling. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-488411
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488411
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر