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Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells
المؤلفون المشاركون
D’Anselmi, Fabrizio
Coluccia, Pierpaolo
Pasqualato, Alessia
Palombo, Alessandro
Morini, Veronica
Cucina, Alessandra
Proietti, Sara
Masiello, Maria Grazia
Dinicola, Simona
Bizzarri, Mariano
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Microgravity exerts dramatic effects on cell morphology and functions, by disrupting cytoskeleton and adhesion structures, as well as by interfering with biochemical pathways and gene expression.
Impairment of cells behavior has both practical and theoretical significance, given that investigations of mechanisms involved in microgravity-mediated effects may shed light on how biophysical constraints cooperate in shaping complex living systems.
By exposing breast cancer MDA-MB-231 cells to simulated microgravity (~0.001 g), we observed the emergence of two morphological phenotypes, characterized by distinct membrane fractal values, surface area, and roundness.
Moreover, the two phenotypes display different aggregation profiles and adherent behavior on the substrate.
These morphological differences are mirrored by the concomitant dramatic functional changes in cell processes (proliferation and apoptosis) and signaling pathways (ERK, AKT, and Survivin).
Furthermore, cytoskeleton undergoes a dramatic reorganization, eventually leading to a very different configuration between the two populations.
These findings could be considered adaptive and reversible features, given that, by culturing microgravity-exposed cells into a normal gravity field, cells are enabled to recover their original phenotype.
Overall these data outline the fundamental role gravity plays in shaping form and function in living systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masiello, Maria Grazia& Cucina, Alessandra& Proietti, Sara& Palombo, Alessandro& Coluccia, Pierpaolo& D’Anselmi, Fabrizio…[et al.]. 2014. Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masiello, Maria Grazia…[et al.]. Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-488429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masiello, Maria Grazia& Cucina, Alessandra& Proietti, Sara& Palombo, Alessandro& Coluccia, Pierpaolo& D’Anselmi, Fabrizio…[et al.]. Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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