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An Investigation of the Significance of Residual Confounding Effect
المؤلفون المشاركون
Liang, Wenbin
Lee, Andy H.
Zhao, Yuejen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Observational studies are commonly conducted in health research.
However, due to their lack of randomization, the estimated associations between the outcome and the exposure can be affected by unmeasured confounding factors.
It is important to determine how likely a significant association observed between an outcome variable and a noncausally related exposure may be introduced by residual confounding factors.
Methods.
A simulation approach is developed based on the sufficient cause model to test the likelihood of significant associations observed between a noncausally related exposure and the outcome.
Results.
Based on the estimates from all 500 replicates, the association between the exposure and the outcome is found to be significant in 386 (77%) replicates when all confounders (component causes) are controlled for in the model.
However, when a subset of real component causes and some noncausal factors are controlled for in the model, the association between exposure and the outcome becomes significant in 487 (97%) replicates.
Conclusion.
Even when all confounding factors are known and controlled for using conventional multivariate analysis, the observed association between exposure and outcome can still be dominated by residual confounding effects.
Therefore, an observed significant association apparently provides limited evidence for a causal relationship.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Wenbin& Zhao, Yuejen& Lee, Andy H.. 2014. An Investigation of the Significance of Residual Confounding Effect. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-488860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Wenbin…[et al.]. An Investigation of the Significance of Residual Confounding Effect. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-488860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Wenbin& Zhao, Yuejen& Lee, Andy H.. An Investigation of the Significance of Residual Confounding Effect. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-488860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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